Gated Luminescence Imaging of Silicon Nanoparticles
Jinmyoung Joo , Xiangyou Liu , Venkata Ramana Kotamraju , Erkki Ruoslahti , Yoonkey Nam , and Michael J. Sailor
In this work, Prof. Nam developed imaging instrumentation and data analysis method while he was staying in Dr. Sailor's group for his sabbatical. He lead the project for 6 month and the project was taken over by Dr. Joo who successfully applied it to tumor tissues. This work uses time-resolved photoluminescence imaging technique to locate drug-loaded porous silicon nanoparticles that has extremely long life-time compared to conventional fluorescence probe molecules. This is the first technical paper on the instrumentation of time-gated life-time imaging of porous silicon nanoparticles using an intensified CCD camera and pulsed LED light sources. (Link)
Minjee Jang's work on agarose-assisted microstamping method was selected as the cover article. Dae-Jeong Kim helped to design the cover image.
Agarose-assisted micro-contact printing uses a stamp covered with agarose thin film, enabling the effective patterning of biomolecules to guide neuronal growth on the substrate. Various patterns including dots with a few micrometers in diameter are also available to be patterned using the method presented by M. J. Jang and Y. Nam on page 613. (Cover designed by M. J. Jang and D. J. Kim.)
Source: Jang et al., Macro. Bioscience 2015 (link)