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MinJee's recent work published at Journal of Neural Engineering has been highlighted in mass media. "Triangles guide the way for live neural circuits in a dish Korean scientists have used tiny stars, squares and triangles as a toolkit to create live neural circuits in a dish.
Published today, 20 July, in IOP Publishing’s Journal of Neural Engineering, the study, by researchers at the Korea Advanced Institute of Science and Technology (KAIST), found that triangles were the most effective shape for helping to facilitate the growth of axons and guide them onto specific paths to form a complete circuit.
Co-author of the study, Professor Yoonkey Nam, said: “Eventually, we want to know if we can design a neural tissue model that biologically mimics some neural circuits in our brain.” Geometric effect of cell adhesive polygonal micropatterns on neuritogenesis and axon guidance. Min Jee Jang and Yoonkey Nam*
This work investigated the shape effect of micro-printed chemical cues on neuronal development in vitro. We found that triangle shapes can be used to control neurite outgrowth and axonal development in vitro. (Link) Aqueous micro-contact printing of cell-adhesive biomolecules for patterning neuronal cell cultures, Min Jee Jang and Yoonkey Nam*. This work shows that conventional micro-contact printing can be done under the aqueous conditions withtout compromising the minimum printable feature sizes. This method will overcome some limitations of micro-contact printings used for creating live neural circuits in vitro. (Link)
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Korea Advanced Institute of Science and Technology (KAIST)
291 Daehak-ro, Yuseong-gu Daejeon 34141, Republic of Korea https://www.kaist.ac.kr Phone: +82-42-350-5362 |
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