Photothermal Inhibition of Neural Activity with Near-Infrared-Sensitive Nanotransducers
Sangjin Yoo, Soonwoo Hong, Yeonho Choi, Ji-Ho Park*, and Yoonkey Nam*
This work reports a novel finding of photothermal inhibition of neuronal spiking activity using NIR sensitive gold nanorods. We showed that action potentials were effectively inhibited at a single cell level, and thus the neural spike rates can be modulated through the light-mediated thermal stimulation. Furthermore, thermo-sensitive potassium channel was involved in the inhibition effect. Sangjin Yoo, who lead this project for 3 years, has been co-advised by Prof. Ji-ho Park in our department. Prof. Y. Choi and his student Mr. Hong at Korea University also contributed in calculating the temperature profile of the gold-nanorods.
Source: Yoo et al., ACS Nano 2014 (Link)