Inkjet-Printed Bio-Functional Thermo-Plasmonic Interfaces for Patterned Neuromodulation
Hongki Kang, Gu-Haeng Lee, Hyunjun Jung, Jee Woong Lee, Yoonkey Nam*
Based on our previous contributions on nanoplamonic neural interface platform (2014, 2016), we made another big step toward the design of plasmonic neural interface devices by adopting state-of-the-art inkjet printing technology. We propose an innovative, but also practically very efficient, approach to fabricate sophisticated thermo-plasmonic micropatterns on any type of substrates (rigid/flexible, hydrophobic/hydrophilic) using NIR-sensitive gold nanorods. We found that integrating polyelectrolyte layer-by-layer assembly with inkjet printing can provide excellent pattern fidelity and uniformity of micro-patterned thermo-plasmonic nanoparticles on various substrates for neuromodulation. With this printing process, we demonstrated that thermo-plasmonic heat sources can be fabricated over very large area (a few cm scale) with great design flexibility. Moreover, the bio-functionality of this high quality thermo-plasmonic interface was also confirmed by selectively modulating electrical activity of in vitro neuronal networks.
Source: Kang et al., ACS Nano 2018 (link)