Inkjet-Printed Bio-Functional Thermo-Plasmonic Interfaces for Patterned Neuromodulation
Hongki Kang, Gu-Haeng Lee, Hyunjun Jung, Jee Woong Lee, Yoonkey Nam*
Based on our previous contributions on nanoplamonic neural interface platform to your journal (2014, 2016), we made another big step toward the design of plasmonic neural interface devices by adopting state-of-the-art inkjet printing technology. We propose an innovative, but also practically very efficient, approach to fabricate sophisticated thermo-plasmonic micropatterns on any type of substrates (rigid/flexible, hydrophobic/hydrophilic) using NIR-sensitive gold nanorods. We found that integrating polyelectrolyte layer-by-layer assembly with inkjet printing can provide excellent pattern fidelity and uniformity of micro-patterned thermo-plasmonic nanoparticles on various substrates for neuromodulation. With this printing process, we demonstrated that thermo-plasmonic heat sources can be fabricated over very large area (a few cm scale) with great design flexibility. Moreover, the bio-functionality of this high quality thermo-plasmonic interface was also confirmed by selectively modulating electrical activity of in vitro neuronal networks.
Source: Kang et al., ACS Nano 2018 (link)